What is segmentation?
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With segmentation you can send your newsletter to a part (segment) of your list.
That can be very convenient, for example, if you want to send your newsletter only to women, to subscribers with a Gmail address, to subscribers born after 1 January 1990, to your subscribers from the province of Gelderland or to subscribers who clicked on a certain link in your last newsletter.
You can also create a segment that meets all the above criteria. This segment then contains all women in Gelderland with a Gmail address, who were born after 1 January 1990 and who clicked on a certain link in the last newsletter.