What is segmentation?
With segmentation, you can divide split your list(s) into different segments. This allows you to send a newsletter to a part (segment) of your list.
That can be very useful, for instance when you only want to send your newsletter to women, to subscribers with a Gmail address, subscribers born after January 1st 1990, to your subscribers located in Amsterdam, or to subscribers who have clicked a certain link in your last newsletter.
You can also create segments where multiple conditions are met. For example, all of the criteria mentioned above; that segment will then contain all female subscribers from Amsterdam, with a Gmail address, born after January 1st 1990, and who have clicked a particular link in your last newsletter.